Assay Detail
Binding
CHEMBL916388
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Displacement of [11,12-3H]ARTA from RARalpha
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.61 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.05 |
| CHEMBL57765 | — | — | 1 | 4.70 |
| CHEMBL388283 | — | — | 1 | 4.70 |
| CHEMBL387639 | — | — | 1 | 4.00 |
| CHEMBL388064 | — | — | 1 | - |
| CHEMBL53449 | — | — | 1 | - |
| CHEMBL417769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL57765 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL388283 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL387639 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL388064 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL53449 | — | IC50 | = | 410000.0 | nM | - |
| CHEMBL417769 | — | IC50 | > | 1000000.0 | nM | - |