Assay Detail
ADMET
CHEMBL916474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT29 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triterpenoid pyrazines and benzopyrazines with cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.76 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222760 | — | — | 1 | 5.70 |
| CHEMBL153117 | — | — | 1 | 5.16 |
| CHEMBL221890 | — | — | 1 | 4.80 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 4.77 |
| CHEMBL376049 | — | — | 1 | 4.11 |
| CHEMBL222651 | — | — | 1 | 4.02 |
| CHEMBL387323 | — | — | 1 | - |
| CHEMBL222652 | — | — | 1 | - |
| CHEMBL376864 | — | — | 1 | - |
| CHEMBL222586 | — | — | 1 | - |
| CHEMBL267420 | — | — | 1 | - |
| CHEMBL345734 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222760 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL153117 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL221890 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL376049 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL222651 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL387323 | — | IC50 | = | 229000.0 | nM | - |
| CHEMBL222652 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL376864 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL222586 | — | IC50 | = | 164000.0 | nM | - |
| CHEMBL267420 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL345734 | — | IC50 | = | 250000.0 | nM | - |