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Assay Detail

CHEMBL916489

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ADMET
Cytotoxicity against human COLO205 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type COLO 205
Confidence 1 — Organism
Curated By Autocuration

Target

COLO 205 (CHEMBL614561)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.
Das U, Alcorn J, Shrivastav A, Sharma RK, De Clercq E, Balzarini J, Dimmock JR.
Eur J Med Chem (2007) 42 : 71 -80
PubMed 16996657 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.26 5.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL540960 1 5.99
CHEMBL455005 1 5.94
CHEMBL154716 1 5.81
CHEMBL463639 1 5.77
CHEMBL464493 1 5.58
CHEMBL185 FLUOROURACIL 4.0 1 5.47
CHEMBL499648 1 5.16
CHEMBL228210 1 5.05
CHEMBL455550 1 4.80
CHEMBL227188 1 4.69
CHEMBL464670 1 4.64
CHEMBL852 MELPHALAN 4.0 1 4.18

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL540960 IC50 = 1020.0 nM 5.99
CHEMBL455005 IC50 = 1150.0 nM 5.94
CHEMBL154716 IC50 = 1550.0 nM 5.81
CHEMBL463639 IC50 = 1700.0 nM 5.77
CHEMBL464493 IC50 = 2630.0 nM 5.58
CHEMBL185 FLUOROURACIL IC50 = 3390.0 nM 5.47
CHEMBL499648 IC50 = 6920.0 nM 5.16
CHEMBL228210 IC50 = 8910.0 nM 5.05
CHEMBL455550 IC50 = 15800.0 nM 4.80
CHEMBL227188 IC50 = 20400.0 nM 4.69
CHEMBL464670 IC50 = 22900.0 nM 4.64
CHEMBL852 MELPHALAN IC50 = 66100.0 nM 4.18