Assay Detail
Functional
CHEMBL916657
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Apoptosis induction in human HT29 cells after 24 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.83 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226923 | — | — | 1 | 5.06 |
| CHEMBL387643 | — | — | 1 | 5.03 |
| CHEMBL227522 | — | — | 1 | 4.40 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
| CHEMBL73188 | — | — | 1 | - |
| CHEMBL228226 | — | — | 1 | - |
| CHEMBL227595 | — | — | 1 | - |
| CHEMBL374385 | NCX-4016 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226923 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL387643 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL227522 | — | EC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL25 | ASPIRIN | EC50 | > | 1000000.0 | nM | - |
| CHEMBL73188 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL228226 | — | EC50 | = | 106700.0 | nM | - |
| CHEMBL227595 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL374385 | NCX-4016 | EC50 | = | 1000000.0 | nM | - |