Assay Detail
Binding
CHEMBL916662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DPP4
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.99 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375508 | — | — | 1 | 8.40 |
| CHEMBL425483 | — | — | 1 | 8.40 |
| CHEMBL227676 | — | — | 1 | 8.30 |
| CHEMBL389074 | — | — | 1 | 8.30 |
| CHEMBL227464 | — | — | 1 | 8.30 |
| CHEMBL227670 | — | — | 1 | 8.10 |
| CHEMBL227954 | — | — | 1 | 7.89 |
| CHEMBL390529 | — | — | 1 | 7.89 |
| CHEMBL228004 | — | — | 1 | 7.82 |
| CHEMBL227356 | — | — | 1 | 7.75 |
| CHEMBL227089 | — | — | 1 | 7.72 |
| CHEMBL387552 | — | — | 1 | 7.54 |
| CHEMBL390776 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375508 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL425483 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL227676 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL389074 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL227464 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL227670 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL227954 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL390529 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL228004 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL227356 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL227089 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL387552 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL390776 | — | IC50 | = | 30.0 | nM | 7.52 |