Assay Detail
Functional
CHEMBL916795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PAF-induced platelet aggregation in rabbit platelet-rich plasma
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.93 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375809 | — | — | 1 | 6.80 |
| CHEMBL269131 | — | — | 1 | 6.43 |
| CHEMBL269340 | — | — | 1 | 6.17 |
| CHEMBL390783 | — | — | 1 | 5.80 |
| CHEMBL375865 | — | — | 1 | 5.30 |
| CHEMBL6322 | PMS-601 | — | 1 | 5.10 |
| CHEMBL222925 | — | — | 1 | - |
| CHEMBL388847 | — | — | 1 | - |
| CHEMBL388846 | — | — | 1 | - |
| CHEMBL388845 | — | — | 1 | - |
| CHEMBL389953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375809 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL269131 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL269340 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL390783 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL375865 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL6322 | PMS-601 | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL222925 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL388847 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL388846 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL388845 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL389953 | — | IC50 | > | 10000.0 | nM | - |