Assay Detail
Functional
CHEMBL916827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of MTX-resistant human CCRF-CEM R2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | R2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.40 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.68 |
| CHEMBL388340 | — | — | 1 | 5.61 |
| CHEMBL224868 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL388340 | — | EC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL224868 | — | EC50 | = | 12000.0 | nM | 4.92 |