Assay Detail
Binding
CHEMBL917014
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Inhibition of human uPA
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 7.50 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226714 | — | — | 1 | 8.85 |
| CHEMBL228113 | — | — | 1 | 8.80 |
| CHEMBL227607 | — | — | 1 | 8.59 |
| CHEMBL374378 | — | — | 1 | 8.24 |
| CHEMBL227666 | — | — | 1 | 8.13 |
| CHEMBL228170 | — | — | 1 | 8.13 |
| CHEMBL227976 | — | — | 1 | 8.10 |
| CHEMBL227421 | — | — | 1 | 8.00 |
| CHEMBL227990 | — | — | 1 | 8.00 |
| CHEMBL227931 | — | — | 1 | 8.00 |
| CHEMBL228204 | — | — | 1 | 7.96 |
| CHEMBL227890 | — | — | 1 | 7.96 |
| CHEMBL228173 | — | — | 1 | 7.85 |
| CHEMBL227422 | — | — | 1 | 7.72 |
| CHEMBL223864 | — | — | 1 | 7.68 |
| CHEMBL266435 | — | — | 1 | 7.66 |
| CHEMBL388780 | — | — | 1 | 7.64 |
| CHEMBL376763 | — | — | 1 | 7.57 |
| CHEMBL227426 | — | — | 1 | 7.55 |
| CHEMBL228172 | — | — | 1 | 7.54 |
| CHEMBL427456 | — | — | 1 | 7.52 |
| CHEMBL227425 | — | — | 1 | 7.51 |
| CHEMBL227995 | — | — | 1 | 7.46 |
| CHEMBL227606 | — | — | 1 | 7.37 |
| CHEMBL226716 | — | — | 1 | 7.32 |
| CHEMBL390133 | — | — | 1 | 7.27 |
| CHEMBL227664 | — | — | 1 | 7.27 |
| CHEMBL227584 | — | — | 1 | 7.24 |
| CHEMBL224689 | — | — | 1 | 7.23 |
| CHEMBL389056 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226714 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL228113 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL227607 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL374378 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL227666 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL228170 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL227976 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL227421 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL227990 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL227931 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL228204 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL227890 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL228173 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL227422 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL223864 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL266435 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL388780 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL376763 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL227426 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL228172 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL427456 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL227425 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL227995 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL227606 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL226716 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL390133 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL227664 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL227584 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL224689 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL389056 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL228052 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL390310 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL374623 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL228238 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL227940 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL227782 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL389032 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL227781 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL227583 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL227769 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL228051 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL227770 | — | Ki | = | 550.0 | nM | 6.26 |