Assay Detail
Binding
CHEMBL917015
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Inhibition of human tPA
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 4.54 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227781 | — | — | 1 | 4.82 |
| CHEMBL228173 | — | — | 1 | 4.64 |
| CHEMBL227607 | — | — | 1 | 4.64 |
| CHEMBL227583 | — | — | 1 | 4.62 |
| CHEMBL226714 | — | — | 1 | 4.46 |
| CHEMBL228113 | — | — | 1 | 4.46 |
| CHEMBL227422 | — | — | 1 | 4.42 |
| CHEMBL374378 | — | — | 1 | 4.42 |
| CHEMBL227421 | — | — | 1 | 4.40 |
| CHEMBL228051 | — | — | 1 | - |
| CHEMBL227890 | — | — | 1 | - |
| CHEMBL223864 | — | — | 1 | - |
| CHEMBL227426 | — | — | 1 | - |
| CHEMBL227606 | — | — | 1 | - |
| CHEMBL376763 | — | — | 1 | - |
| CHEMBL227931 | — | — | 1 | - |
| CHEMBL227782 | — | — | 1 | - |
| CHEMBL388780 | — | — | 1 | - |
| CHEMBL228238 | — | — | 1 | - |
| CHEMBL389032 | — | — | 1 | - |
| CHEMBL390133 | — | — | 1 | - |
| CHEMBL228204 | — | — | 1 | - |
| CHEMBL228052 | — | — | 1 | - |
| CHEMBL427456 | — | — | 1 | - |
| CHEMBL227769 | — | — | 1 | - |
| CHEMBL390310 | — | — | 1 | - |
| CHEMBL227940 | — | — | 1 | - |
| CHEMBL374623 | — | — | 1 | - |
| CHEMBL227770 | — | — | 1 | - |
| CHEMBL224689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227781 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL228173 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL227607 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL227583 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL226714 | — | Ki | = | 34700.0 | nM | 4.46 |
| CHEMBL228113 | — | Ki | = | 34400.0 | nM | 4.46 |
| CHEMBL227422 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL374378 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL227421 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL227931 | — | Ki | = | 108000.0 | nM | - |
| CHEMBL227584 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227782 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL388780 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL228238 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227990 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227666 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227976 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL228170 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL226716 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL266435 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL389056 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227425 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227995 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL228172 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227664 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL228204 | — | Ki | - | — | - | |
| CHEMBL224689 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227770 | — | Ki | - | — | - | |
| CHEMBL374623 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL227940 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL390310 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL227769 | — | Ki | - | — | - | |
| CHEMBL427456 | — | Ki | - | — | - | |
| CHEMBL228052 | — | Ki | - | — | - | |
| CHEMBL376763 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL390133 | — | Ki | - | — | - | |
| CHEMBL389032 | — | Ki | - | — | - | |
| CHEMBL228051 | — | Ki | - | — | - | |
| CHEMBL227890 | — | Ki | - | — | - | |
| CHEMBL223864 | — | Ki | - | — | - | |
| CHEMBL227426 | — | Ki | - | — | - | |
| CHEMBL227606 | — | Ki | - | — | - |