Assay Detail
Binding
CHEMBL917037
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Inhibition of Escherichia coli AmpC beta lactamase using relaxed assay conditions in presence of 0.00001% Triton X-100 detergent
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
A high-throughput screen for aggregation-based inhibition in a large compound library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.64 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227726 | — | — | 1 | 4.89 |
| CHEMBL1221 | SULCONAZOLE | 4.0 | 1 | 4.70 |
| CHEMBL227512 | — | — | 1 | 4.70 |
| CHEMBL226664 | — | — | 1 | 4.70 |
| CHEMBL31741 | — | — | 1 | 4.66 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.46 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 4.34 |
| CHEMBL1479675 | — | — | 1 | - |
| CHEMBL227496 | — | — | 1 | - |
| CHEMBL16223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227726 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1221 | SULCONAZOLE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL227512 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL226664 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL31741 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1479675 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL227496 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL16223 | — | IC50 | > | 100000.0 | nM | - |