Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL917093

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human E-selectin after 2 hrs
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

E-selectin (CHEMBL3890)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Rational design of novel, potent small molecule pan-selectin antagonists.
Kranich R, Busemann AS, Bock D, Schroeter-Maas S, Beyer D, Heinemann B, Meyer M, Schierhorn K, Zahlten R, Wolff G, Aydt EM.
J Med Chem (2007) 50 : 1101 -1115
PubMed 17302397 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 4.98 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL221163 1 6.10
CHEMBL220255 1 6.00
CHEMBL220560 1 5.89
CHEMBL220419 1 5.64
CHEMBL220997 1 5.52
CHEMBL376200 1 5.51
CHEMBL386951 1 5.48
CHEMBL220828 1 5.31
CHEMBL220721 1 5.08
CHEMBL221111 1 5.08
CHEMBL424929 1 5.06
CHEMBL375763 1 5.01
CHEMBL220720 1 4.80
CHEMBL220338 1 4.73
CHEMBL374735 1 4.50
CHEMBL220565 1 4.38
CHEMBL223010 1 4.32
CHEMBL223009 1 4.31
CHEMBL220208 1 4.28
CHEMBL220340 1 4.24
CHEMBL373592 1 4.21
CHEMBL426378 1 4.07
CHEMBL1215923 BIMOSIAMOSE 2.0 1 -
CHEMBL375429 1 -
CHEMBL220046 1 -
CHEMBL288114 GALLIC ACID 2.0 1 -
CHEMBL220779 1 -
CHEMBL220254 1 -
CHEMBL220776 1 -
CHEMBL221041 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL221163 IC50 = 800.0 nM 6.10
CHEMBL220255 IC50 = 1000.0 nM 6.00
CHEMBL220560 IC50 = 1300.0 nM 5.89
CHEMBL220419 IC50 = 2300.0 nM 5.64
CHEMBL220997 IC50 = 3000.0 nM 5.52
CHEMBL376200 IC50 = 3100.0 nM 5.51
CHEMBL386951 IC50 = 3300.0 nM 5.48
CHEMBL220828 IC50 = 4900.0 nM 5.31
CHEMBL220721 IC50 = 8400.0 nM 5.08
CHEMBL221111 IC50 = 8400.0 nM 5.08
CHEMBL424929 IC50 = 8700.0 nM 5.06
CHEMBL375763 IC50 = 9700.0 nM 5.01
CHEMBL220720 IC50 = 15700.0 nM 4.80
CHEMBL220338 IC50 = 18700.0 nM 4.73
CHEMBL374735 IC50 = 31700.0 nM 4.50
CHEMBL220565 IC50 = 41900.0 nM 4.38
CHEMBL223010 IC50 = 48000.0 nM 4.32
CHEMBL223009 IC50 = 48600.0 nM 4.31
CHEMBL220208 IC50 = 52400.0 nM 4.28
CHEMBL220340 IC50 = 57200.0 nM 4.24
CHEMBL373592 IC50 = 61400.0 nM 4.21
CHEMBL426378 IC50 = 85400.0 nM 4.07
CHEMBL386952 IC50 = 132000.0 nM -
CHEMBL221273 IC50 = 113700.0 nM -
CHEMBL375586 SIALYL LEWIS X IC50 = 134200.0 nM -
CHEMBL219991 IC50 > 500000.0 nM -
CHEMBL221161 IC50 > 500000.0 nM -
CHEMBL426376 IC50 > 500000.0 nM -
CHEMBL374927 IC50 > 500000.0 nM -
CHEMBL387380 IC50 > 500000.0 nM -
CHEMBL221041 IC50 > 500000.0 nM -
CHEMBL220776 IC50 > 500000.0 nM -
CHEMBL220254 IC50 > 500000.0 nM -
CHEMBL220779 IC50 > 500000.0 nM -
CHEMBL288114 GALLIC ACID IC50 > 500000.0 nM -
CHEMBL220046 IC50 - -
CHEMBL375429 IC50 > 500000.0 nM -
CHEMBL1215923 BIMOSIAMOSE IC50 > 500000.0 nM -