Assay Detail
Binding
CHEMBL917136
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Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.29 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117862 | — | — | 1 | 7.05 |
| CHEMBL435381 | CIMICOXIB | 2.0 | 1 | 7.00 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.89 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 5.82 |
| CHEMBL223619 | — | — | 1 | 5.16 |
| CHEMBL373819 | — | — | 1 | 4.85 |
| CHEMBL376246 | — | — | 1 | 4.80 |
| CHEMBL220113 | — | — | 1 | 4.70 |
| CHEMBL223529 | — | — | 1 | 4.54 |
| CHEMBL219893 | — | — | 1 | 4.25 |
| CHEMBL373867 | — | — | 1 | 4.12 |
| CHEMBL386006 | — | — | 1 | - |
| CHEMBL219885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117862 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL435381 | CIMICOXIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL118 | CELECOXIB | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL223619 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL373819 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL376246 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL220113 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL223529 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL219893 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL373867 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL386006 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL219885 | — | IC50 | > | 100000.0 | nM | - |