Assay Detail
Binding
CHEMBL917141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flumazenil from benzodiazepine receptor in bovine brain membranes
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Subcellular | Brain membranes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.62 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452 | CLONAZEPAM | 4.0 | 1 | 9.07 |
| CHEMBL407 | FLUMAZENIL | 4.0 | 1 | 9.05 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.00 |
| CHEMBL375367 | — | — | 1 | 7.24 |
| CHEMBL223707 | — | — | 1 | 7.06 |
| CHEMBL376508 | — | — | 1 | 7.03 |
| CHEMBL222316 | — | — | 1 | 6.96 |
| CHEMBL75307 | — | — | 1 | 6.93 |
| CHEMBL75289 | — | — | 1 | 6.92 |
| CHEMBL373871 | — | — | 1 | 6.79 |
| CHEMBL220373 | — | — | 1 | 6.38 |
| CHEMBL220737 | — | — | 1 | 6.22 |
| CHEMBL373662 | — | — | 1 | 5.83 |
| CHEMBL223152 | — | — | 1 | 5.78 |
| CHEMBL385100 | — | — | 1 | 5.67 |
| CHEMBL376064 | — | — | 1 | 5.57 |
| CHEMBL373462 | — | — | 1 | 5.55 |
| CHEMBL374536 | — | — | 1 | 5.49 |
| CHEMBL223476 | — | — | 1 | 5.43 |
| CHEMBL223480 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452 | CLONAZEPAM | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL407 | FLUMAZENIL | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL12 | DIAZEPAM | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL375367 | — | Ki | = | 57.8 | nM | 7.24 |
| CHEMBL223707 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL376508 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL222316 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL75307 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL75289 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL373871 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL220373 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL220737 | — | Ki | = | 606.0 | nM | 6.22 |
| CHEMBL373662 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL223152 | — | Ki | = | 1650.0 | nM | 5.78 |
| CHEMBL385100 | — | Ki | = | 2160.0 | nM | 5.67 |
| CHEMBL376064 | — | Ki | = | 2690.0 | nM | 5.57 |
| CHEMBL373462 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL374536 | — | Ki | = | 3275.0 | nM | 5.49 |
| CHEMBL223476 | — | Ki | = | 3720.0 | nM | 5.43 |
| CHEMBL223480 | — | Ki | = | 4100.0 | nM | 5.39 |