Assay Detail
Functional
CHEMBL917394
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Cytotoxicity activity against Leishmania infantum after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.10 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266285 | — | — | 1 | 6.33 |
| CHEMBL228066 | BNIPSPD | — | 1 | 6.33 |
| CHEMBL373510 | BNIPDETA | — | 1 | 6.13 |
| CHEMBL268910 | BNIPDETA | — | 1 | 6.13 |
| CHEMBL224065 | BNIPDANON | — | 1 | 6.11 |
| CHEMBL224383 | BNIPDAOCT | — | 1 | 6.11 |
| CHEMBL228002 | BNIPDANON | — | 1 | 6.11 |
| CHEMBL228067 | BNIPDAOCT | — | 1 | 6.11 |
| CHEMBL223816 | BNIPDPTA | — | 1 | 5.81 |
| CHEMBL228068 | BNIPDPTA | — | 1 | 5.81 |
| CHEMBL224440 | BNIPDADEC | — | 1 | - |
| CHEMBL268909 | BNIPDADEC | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266285 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL228066 | BNIPSPD | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL373510 | BNIPDETA | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL268910 | BNIPDETA | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL224065 | BNIPDANON | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL224383 | BNIPDAOCT | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL228002 | BNIPDANON | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL228067 | BNIPDAOCT | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL223816 | BNIPDPTA | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL228068 | BNIPDPTA | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL224440 | BNIPDADEC | IC50 | - | — | - | |
| CHEMBL268909 | BNIPDADEC | IC50 | - | — | - |