Assay Detail
Binding
CHEMBL917719
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Inhibition of BACE1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.49 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377625 | — | — | 1 | 8.00 |
| CHEMBL376277 | — | — | 1 | 7.85 |
| CHEMBL221454 | — | — | 1 | 7.82 |
| CHEMBL266891 | — | — | 1 | 7.82 |
| CHEMBL376072 | — | — | 1 | 7.82 |
| CHEMBL225442 | — | — | 1 | 7.64 |
| CHEMBL162970 | — | — | 1 | 7.39 |
| CHEMBL222209 | — | — | 1 | 7.20 |
| CHEMBL426717 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377625 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL376277 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL221454 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL266891 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL376072 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL225442 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL162970 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL222209 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL426717 | — | IC50 | = | 1400.0 | nM | 5.85 |