Assay Detail
Binding
CHEMBL917757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP27B hydroxylase expressed in SW900 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW900 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CHEMBL5993) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.26 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389014 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389014 | — | IC50 | = | 554.0 | nM | 6.26 |