Assay Detail
Functional
CHEMBL917774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human CB1 receptor by [35S]GTP-gamma-S binding stimulation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.84 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334533 | DEXANABINOL | 3.0 | 1 | 9.22 |
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 8.00 |
| CHEMBL224627 | — | — | 1 | 6.35 |
| CHEMBL427241 | — | — | 1 | 6.30 |
| CHEMBL436309 | — | — | 1 | 6.16 |
| CHEMBL224113 | — | — | 1 | 5.98 |
| CHEMBL224697 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334533 | DEXANABINOL | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL111 | RIMONABANT | EC50 | = | 10.1 | nM | 8.00 |
| CHEMBL224627 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL427241 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL436309 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL224113 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL224697 | — | EC50 | = | 1250.0 | nM | 5.90 |