Assay Detail
ADMET
CHEMBL917813
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Cytotoxicity against human A549 cells after 3 days by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.89 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224767 | — | — | 1 | 6.89 |
| CHEMBL224647 | — | — | 1 | 6.82 |
| CHEMBL223818 | — | — | 1 | 6.57 |
| CHEMBL375931 | — | — | 1 | 6.48 |
| CHEMBL223961 | — | — | 1 | 6.22 |
| CHEMBL224181 | — | — | 1 | 5.98 |
| CHEMBL11645 | — | — | 1 | 5.80 |
| CHEMBL224724 | — | — | 1 | 5.79 |
| CHEMBL11269 | — | — | 1 | 5.73 |
| CHEMBL387701 | — | — | 1 | 5.72 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.68 |
| CHEMBL224254 | — | — | 1 | 5.45 |
| CHEMBL224794 | — | — | 1 | 5.40 |
| CHEMBL224682 | — | — | 1 | 4.94 |
| CHEMBL224252 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224767 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL224647 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL223818 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL375931 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL223961 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL224181 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL11645 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL224724 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL11269 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL387701 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL224254 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL224794 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL224682 | — | IC50 | = | 11560.0 | nM | 4.94 |
| CHEMBL224252 | — | IC50 | = | 13970.0 | nM | 4.86 |