Assay Detail
ADMET
CHEMBL917815
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Cytotoxicity against human Col2 cells after 3 days by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Col2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.87 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224647 | — | — | 1 | 6.85 |
| CHEMBL224252 | — | — | 1 | 6.85 |
| CHEMBL223961 | — | — | 1 | 6.30 |
| CHEMBL224767 | — | — | 1 | 6.26 |
| CHEMBL11269 | — | — | 1 | 6.24 |
| CHEMBL375931 | — | — | 1 | 5.98 |
| CHEMBL223818 | — | — | 1 | 5.90 |
| CHEMBL224794 | — | — | 1 | 5.80 |
| CHEMBL224181 | — | — | 1 | 5.76 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.74 |
| CHEMBL224724 | — | — | 1 | 5.74 |
| CHEMBL224254 | — | — | 1 | 5.26 |
| CHEMBL387701 | — | — | 1 | 5.15 |
| CHEMBL11645 | — | — | 1 | 5.14 |
| CHEMBL224682 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224647 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL224252 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL223961 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL224767 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL11269 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL375931 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL223818 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL224794 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL224181 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL224724 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL224254 | — | IC50 | = | 5490.0 | nM | 5.26 |
| CHEMBL387701 | — | IC50 | = | 7070.0 | nM | 5.15 |
| CHEMBL11645 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL224682 | — | IC50 | = | 9760.0 | nM | 5.01 |