Assay Detail
ADMET
CHEMBL917840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U937 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro cytotoxicity evaluation of some substituted isatin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.64 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 5.70 |
| CHEMBL376616 | — | — | 1 | 5.17 |
| CHEMBL387839 | — | — | 1 | 5.11 |
| CHEMBL388579 | — | — | 1 | 4.98 |
| CHEMBL388580 | — | — | 1 | 4.94 |
| CHEMBL227601 | — | — | 1 | 4.86 |
| CHEMBL389875 | — | — | 1 | 4.77 |
| CHEMBL325480 | 5-IODOISATIN | — | 1 | 4.27 |
| CHEMBL115897 | — | — | 1 | 4.19 |
| CHEMBL223335 | — | — | 1 | 4.13 |
| CHEMBL227491 | — | — | 1 | 4.12 |
| CHEMBL228239 | — | — | 1 | 4.08 |
| CHEMBL116040 | 5-FLUOROISATIN | — | 1 | 4.01 |
| CHEMBL60569 | — | — | 1 | - |
| CHEMBL228145 | — | — | 1 | - |
| CHEMBL227854 | — | — | 1 | - |
| CHEMBL326294 | ISATIN | — | 1 | - |
| CHEMBL87527 | — | — | 1 | - |
| CHEMBL222660 | 5-METHOXYISATIN | — | 1 | - |
| CHEMBL118305 | 5-NITROISATIN | — | 1 | - |
| CHEMBL226658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL376616 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL387839 | — | IC50 | = | 7850.0 | nM | 5.11 |
| CHEMBL388579 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL388580 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL227601 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL389875 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL325480 | 5-IODOISATIN | IC50 | = | 53400.0 | nM | 4.27 |
| CHEMBL115897 | — | IC50 | = | 64500.0 | nM | 4.19 |
| CHEMBL223335 | — | IC50 | = | 74800.0 | nM | 4.13 |
| CHEMBL227491 | — | IC50 | = | 76500.0 | nM | 4.12 |
| CHEMBL228239 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL116040 | 5-FLUOROISATIN | IC50 | = | 98400.0 | nM | 4.01 |
| CHEMBL60569 | — | IC50 | = | 238000.0 | nM | - |
| CHEMBL228145 | — | IC50 | > | 369000.0 | nM | - |
| CHEMBL227854 | — | IC50 | = | 257000.0 | nM | - |
| CHEMBL326294 | ISATIN | IC50 | = | 565000.0 | nM | - |
| CHEMBL87527 | — | IC50 | > | 211000.0 | nM | - |
| CHEMBL222660 | 5-METHOXYISATIN | IC50 | = | 420000.0 | nM | - |
| CHEMBL118305 | 5-NITROISATIN | IC50 | = | 132000.0 | nM | - |
| CHEMBL226658 | — | IC50 | = | 214000.0 | nM | - |