Assay Detail
Binding
CHEMBL918059
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Inhibition of SARS coronavirus 3C-like protease
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Replicase polyprotein 1a (CHEMBL3927) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.97 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222234 | — | — | 1 | 7.30 |
| CHEMBL222840 | — | — | 1 | 7.22 |
| CHEMBL222769 | — | — | 1 | 7.20 |
| CHEMBL225515 | — | — | 1 | 7.19 |
| CHEMBL222893 | — | — | 1 | 7.02 |
| CHEMBL426898 | — | — | 1 | 6.77 |
| CHEMBL222628 | — | — | 1 | 6.57 |
| CHEMBL222735 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222234 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL222840 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL222769 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL225515 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL222893 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL426898 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL222628 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL222735 | — | IC50 | = | 340.0 | nM | 6.47 |