Assay Detail
Functional
CHEMBL918072
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Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Arylthioindoles, potent inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.39 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.89 |
| CHEMBL221765 | — | — | 1 | 7.89 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.77 |
| CHEMBL389169 | — | — | 1 | 7.60 |
| CHEMBL381933 | — | — | 1 | 7.38 |
| CHEMBL89341 | — | — | 1 | 7.35 |
| CHEMBL145872 | — | — | 1 | 6.80 |
| CHEMBL327414 | — | — | 1 | 6.43 |
| CHEMBL222228 | — | — | 1 | - |
| CHEMBL223922 | — | — | 1 | - |
| CHEMBL390534 | — | — | 1 | - |
| CHEMBL376312 | — | — | 1 | - |
| CHEMBL313011 | — | — | 1 | - |
| CHEMBL313989 | — | — | 1 | - |
| CHEMBL373536 | — | — | 1 | - |
| CHEMBL286404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL221765 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL389169 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL381933 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL89341 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL145872 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL327414 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL222228 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL223922 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL390534 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL376312 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL313011 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL313989 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL373536 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL286404 | — | IC50 | > | 2500.0 | nM | - |