Assay Detail
Binding
CHEMBL918076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human EP3 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.53 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223151 | — | — | 1 | 5.72 |
| CHEMBL222715 | — | — | 1 | 4.96 |
| CHEMBL222677 | — | — | 1 | 4.27 |
| CHEMBL223744 | — | — | 1 | 4.11 |
| CHEMBL222782 | — | — | 1 | 4.10 |
| CHEMBL376347 | — | — | 1 | 4.04 |
| CHEMBL221946 | — | — | 1 | - |
| CHEMBL222834 | — | — | 1 | - |
| CHEMBL224970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223151 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL222715 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL222677 | — | Ki | = | 54000.0 | nM | 4.27 |
| CHEMBL223744 | — | Ki | = | 77000.0 | nM | 4.11 |
| CHEMBL222782 | — | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL376347 | — | Ki | = | 90300.0 | nM | 4.04 |
| CHEMBL221946 | — | Ki | - | — | - | |
| CHEMBL222834 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL224970 | — | Ki | > | 100000.0 | nM | - |