Assay Detail
Functional
CHEMBL918078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional activity at human EP4 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.53 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222677 | — | — | 1 | 10.40 |
| CHEMBL222782 | — | — | 1 | 9.70 |
| CHEMBL222834 | — | — | 1 | 8.23 |
| CHEMBL222715 | — | — | 1 | 7.96 |
| CHEMBL224970 | — | — | 1 | 7.92 |
| CHEMBL223151 | — | — | 1 | 7.77 |
| CHEMBL42027 | — | — | 1 | 7.25 |
| CHEMBL376347 | — | — | 1 | 6.89 |
| CHEMBL223744 | — | — | 1 | 6.82 |
| CHEMBL373558 | — | — | 1 | 6.75 |
| CHEMBL222085 | — | — | 1 | 5.68 |
| CHEMBL376063 | — | — | 1 | 4.97 |
| CHEMBL221946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222677 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL222782 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL222834 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL222715 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL224970 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL223151 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL42027 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL376347 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL223744 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL373558 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL222085 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL376063 | — | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL221946 | — | EC50 | > | 10000.0 | nM | - |