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Assay Detail

CHEMBL918207

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ADMET
Cytotoxicity against human HT29 cells by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition.
Sissi C, Lucatello L, Paul Krapcho A, Maloney DJ, Boxer MB, Camarasa MV, Pezzoni G, Menta E, Palumbo M.
Bioorg Med Chem (2007) 15 : 555 -562
PubMed 17035038 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.54 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL287201 1 6.89
CHEMBL225001 1 6.64
CHEMBL225205 1 5.93
CHEMBL225507 1 5.49
CHEMBL20330 1 5.30
CHEMBL224755 1 5.27
CHEMBL275860 1 5.05
CHEMBL359594 1 5.04
CHEMBL225209 1 4.93
CHEMBL225508 1 4.82
CHEMBL224754 1 -
CHEMBL225312 1 -
CHEMBL280910 1 -
CHEMBL225208 1 -
CHEMBL388102 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL287201 IC50 = 130.0 nM 6.89
CHEMBL225001 IC50 = 230.0 nM 6.64
CHEMBL225205 IC50 = 1170.0 nM 5.93
CHEMBL225507 IC50 = 3240.0 nM 5.49
CHEMBL20330 IC50 = 5050.0 nM 5.30
CHEMBL224755 IC50 = 5400.0 nM 5.27
CHEMBL275860 IC50 = 8890.0 nM 5.05
CHEMBL359594 IC50 = 9020.0 nM 5.04
CHEMBL225209 IC50 = 11700.0 nM 4.93
CHEMBL225508 IC50 = 15200.0 nM 4.82
CHEMBL224754 IC50 >= 100000.0 nM -
CHEMBL225312 IC50 >= 100000.0 nM -
CHEMBL280910 IC50 - -
CHEMBL225208 IC50 >= 100000.0 nM -
CHEMBL388102 IC50 - -