Assay Detail
Functional
CHEMBL918245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCP1-induced cell migration in U937 cells expressing CCR2 by chemotaxis assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of Rho kinase inhibitors (II).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.40 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225582 | — | — | 1 | 6.00 |
| CHEMBL427245 | — | — | 1 | 6.00 |
| CHEMBL415061 | — | — | 1 | 6.00 |
| CHEMBL426925 | — | — | 1 | 6.00 |
| CHEMBL224510 | — | — | 1 | 6.00 |
| CHEMBL427254 | — | — | 1 | 6.00 |
| CHEMBL225637 | — | — | 1 | 6.00 |
| CHEMBL388516 | — | — | 1 | 6.00 |
| CHEMBL225166 | — | — | 1 | 6.00 |
| CHEMBL224535 | — | — | 1 | 5.70 |
| CHEMBL224885 | — | — | 1 | 5.70 |
| CHEMBL390736 | — | — | 1 | 5.52 |
| CHEMBL224509 | — | — | 1 | 5.40 |
| CHEMBL225167 | — | — | 1 | 5.30 |
| CHEMBL390389 | — | — | 1 | 5.30 |
| CHEMBL373512 | — | — | 1 | 5.22 |
| CHEMBL225434 | — | — | 1 | 5.22 |
| CHEMBL388742 | — | — | 1 | 5.16 |
| CHEMBL389168 | — | — | 1 | 5.10 |
| CHEMBL390837 | — | — | 1 | 5.10 |
| CHEMBL386937 | — | — | 1 | 5.00 |
| CHEMBL224166 | — | — | 1 | 5.00 |
| CHEMBL224594 | — | — | 1 | 4.72 |
| CHEMBL389915 | — | — | 1 | 4.72 |
| CHEMBL224746 | — | — | 1 | 4.70 |
| CHEMBL224500 | — | — | 1 | 4.52 |
| CHEMBL541388 | FASUDIL HYDROCHLORIDE | 2.0 | 1 | 4.46 |
| CHEMBL389622 | — | — | 1 | - |
| CHEMBL224533 | — | — | 1 | - |
| CHEMBL225225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225582 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL225166 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL388516 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL225637 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL427254 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL426925 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL415061 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL427245 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL224510 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL224535 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL224885 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL390736 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL224509 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL225167 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL390389 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL373512 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL225434 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL388742 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL389168 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL390837 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL386937 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL224166 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL224594 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL389915 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL224746 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL224500 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL541388 | FASUDIL HYDROCHLORIDE | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL225224 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL223553 | — | IC50 | - | — | - | |
| CHEMBL427085 | — | IC50 | - | — | - | |
| CHEMBL224696 | — | IC50 | - | — | - | |
| CHEMBL224167 | — | IC50 | - | — | - | |
| CHEMBL225168 | — | IC50 | - | — | - | |
| CHEMBL224558 | — | IC50 | - | — | - | |
| CHEMBL225282 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL224559 | — | IC50 | - | — | - | |
| CHEMBL224887 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL224076 | — | IC50 | - | — | - | |
| CHEMBL224077 | — | IC50 | - | — | - | |
| CHEMBL427083 | — | IC50 | - | — | - | |
| CHEMBL223651 | — | IC50 | - | — | - | |
| CHEMBL225226 | — | IC50 | - | — | - | |
| CHEMBL390390 | — | IC50 | - | — | - | |
| CHEMBL224067 | — | IC50 | - | — | - | |
| CHEMBL427103 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL225560 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL225225 | — | IC50 | - | — | - | |
| CHEMBL224533 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL389622 | — | IC50 | > | 30000.0 | nM | - |