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Assay Detail

CHEMBL918628

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Binding
Inhibition of rabbit liver carboxylesterase expressed in sf21 cells
ChEMBL ↗
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Cell Type Sf21
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM.
J Med Chem (2007) 50 : 1876 -1885
PubMed 17378546 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 65 5.59 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL222752 — — 1 8.22
CHEMBL375126 — — 1 7.19
CHEMBL222644 — — 1 7.06
CHEMBL225169 — — 1 6.89
CHEMBL116649 — — 1 6.44
CHEMBL385799 — — 1 6.39
CHEMBL223039 — — 1 6.39
CHEMBL221830 — — 1 6.38
CHEMBL222988 — — 1 6.31
CHEMBL385800 — — 1 6.28
CHEMBL117447 PHENYL ISATIN — 1 6.21
CHEMBL376291 — — 1 6.12
CHEMBL374740 — — 1 6.12
CHEMBL222712 — — 1 5.95
CHEMBL325480 5-IODOISATIN — 1 5.94
CHEMBL374758 — — 1 5.94
CHEMBL385132 — — 1 5.90
CHEMBL115897 — — 1 5.88
CHEMBL222292 — — 1 5.85
CHEMBL376435 — — 1 5.67
CHEMBL376518 — — 1 5.67
CHEMBL376228 — — 1 5.48
CHEMBL426562 — — 1 5.39
CHEMBL327012 — — 1 5.36
CHEMBL222190 — — 1 5.35
CHEMBL222999 — — 1 5.32
CHEMBL375304 — — 1 5.31
CHEMBL223000 — — 1 5.29
CHEMBL118305 5-NITROISATIN — 1 5.19
CHEMBL222851 — — 1 5.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL222752 — Ki = 6.0 nM 8.22
CHEMBL375126 — Ki = 65.0 nM 7.19
CHEMBL222644 — Ki = 88.0 nM 7.06
CHEMBL225169 — Ki = 130.0 nM 6.89
CHEMBL116649 — Ki = 360.0 nM 6.44
CHEMBL385799 — Ki = 410.0 nM 6.39
CHEMBL223039 — Ki = 410.0 nM 6.39
CHEMBL221830 — Ki = 420.0 nM 6.38
CHEMBL222988 — Ki = 490.0 nM 6.31
CHEMBL385800 — Ki = 530.0 nM 6.28
CHEMBL117447 PHENYL ISATIN Ki = 610.0 nM 6.21
CHEMBL376291 — Ki = 750.0 nM 6.12
CHEMBL374740 — Ki = 760.0 nM 6.12
CHEMBL222712 — Ki = 1120.0 nM 5.95
CHEMBL374758 — Ki = 1150.0 nM 5.94
CHEMBL325480 5-IODOISATIN Ki = 1160.0 nM 5.94
CHEMBL385132 — Ki = 1250.0 nM 5.90
CHEMBL115897 — Ki = 1320.0 nM 5.88
CHEMBL222292 — Ki = 1420.0 nM 5.85
CHEMBL376435 — Ki = 2150.0 nM 5.67
CHEMBL376518 — Ki = 2150.0 nM 5.67
CHEMBL376228 — Ki = 3290.0 nM 5.48
CHEMBL426562 — Ki = 4040.0 nM 5.39
CHEMBL327012 — Ki = 4370.0 nM 5.36
CHEMBL222190 — Ki = 4510.0 nM 5.35
CHEMBL222999 — Ki = 4830.0 nM 5.32
CHEMBL375304 — Ki = 4900.0 nM 5.31
CHEMBL223000 — Ki = 5150.0 nM 5.29
CHEMBL118305 5-NITROISATIN Ki = 6430.0 nM 5.19
CHEMBL222851 — Ki = 7400.0 nM 5.13
CHEMBL374331 — Ki = 8290.0 nM 5.08
CHEMBL373781 — Ki = 10500.0 nM 4.98
CHEMBL221669 — Ki = 12100.0 nM 4.92
CHEMBL376290 — Ki = 14100.0 nM 4.85
CHEMBL224822 — Ki = 14600.0 nM 4.84
CHEMBL223785 — Ki = 16100.0 nM 4.79
CHEMBL373715 — Ki = 16700.0 nM 4.78
CHEMBL222149 — Ki = 16700.0 nM 4.78
CHEMBL115581 — Ki = 19000.0 nM 4.72
CHEMBL118883 — Ki = 26200.0 nM 4.58
CHEMBL222660 5-METHOXYISATIN Ki = 26700.0 nM 4.57
CHEMBL374970 — Ki = 27400.0 nM 4.56
CHEMBL374629 — Ki = 29500.0 nM 4.53
CHEMBL333636 — Ki = 30500.0 nM 4.52
CHEMBL442046 — Ki = 34900.0 nM 4.46
CHEMBL221512 — Ki > 100000.0 nM -
CHEMBL375078 — Ki > 100000.0 nM -
CHEMBL223254 — Ki > 100000.0 nM -
CHEMBL222795 — Ki > 100000.0 nM -
CHEMBL374905 — Ki > 100000.0 nM -