Assay Detail
Binding
CHEMBL918668
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Displacement of [3H]BTX-B from voltage gated sodium channel in rat cerebral cortex synaptoneurosomes
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship studies for hydantoins and analogues as voltage-gated sodium channel ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.14 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225189 | — | — | 1 | 6.66 |
| CHEMBL225170 | — | — | 1 | 5.96 |
| CHEMBL373877 | — | — | 1 | 5.89 |
| CHEMBL225495 | — | — | 1 | 5.66 |
| CHEMBL225408 | — | — | 1 | 5.60 |
| CHEMBL376544 | — | — | 1 | 5.48 |
| CHEMBL222105 | — | — | 1 | 5.37 |
| CHEMBL222210 | — | — | 1 | 5.35 |
| CHEMBL425125 | — | — | 1 | 5.32 |
| CHEMBL39043 | — | — | 1 | 5.30 |
| CHEMBL225405 | — | — | 1 | 5.30 |
| CHEMBL417155 | — | — | 1 | 5.30 |
| CHEMBL374113 | — | — | 1 | 5.29 |
| CHEMBL540451 | — | — | 1 | 5.28 |
| CHEMBL225197 | — | — | 1 | 5.20 |
| CHEMBL222208 | — | — | 1 | 5.19 |
| CHEMBL373380 | — | — | 1 | 5.16 |
| CHEMBL387956 | — | — | 1 | 5.09 |
| CHEMBL287713 | — | — | 1 | 5.05 |
| CHEMBL388171 | — | — | 1 | 4.96 |
| CHEMBL388327 | — | — | 1 | 4.96 |
| CHEMBL376661 | — | — | 1 | 4.89 |
| CHEMBL376872 | — | — | 1 | 4.52 |
| CHEMBL376560 | — | — | 1 | 4.52 |
| CHEMBL373470 | — | — | 1 | 4.46 |
| CHEMBL225389 | — | — | 1 | 4.44 |
| CHEMBL288505 | — | — | 1 | 4.41 |
| CHEMBL224836 | — | — | 1 | 4.29 |
| CHEMBL222910 | — | — | 1 | 4.08 |
| CHEMBL288861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225189 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL225170 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL373877 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL225495 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL225408 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL376544 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL222105 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL222210 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL425125 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL39043 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL225405 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL417155 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL374113 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL540451 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL225197 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL222208 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL373380 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL387956 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL287713 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL388171 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL388327 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL376661 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL376872 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL376560 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL373470 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL225389 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL288505 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL224836 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL222910 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL221785 | — | IC50 | = | 178000.0 | nM | - |
| CHEMBL225140 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL445584 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL225253 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL225648 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL275861 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL224848 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1438 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL221365 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL390536 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL222042 | — | IC50 | = | 274000.0 | nM | - |
| CHEMBL222770 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL309487 | ATROLACTAMIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL221361 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL222263 | — | IC50 | = | 448000.0 | nM | - |
| CHEMBL374202 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL221456 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL39010 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL225586 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL225585 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL288861 | — | IC50 | = | 162000.0 | nM | - |