Assay Detail
Functional
CHEMBL918692
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Inhibition of subgenomic HCV RNA replication in Huh7 cells by cell-based replicon assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 5.15 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376487 | — | — | 1 | 5.77 |
| CHEMBL221711 | — | — | 1 | 5.62 |
| CHEMBL376874 | — | — | 1 | 5.62 |
| CHEMBL221969 | — | — | 1 | 5.52 |
| CHEMBL384660 | — | — | 1 | 5.47 |
| CHEMBL389645 | — | — | 1 | 5.46 |
| CHEMBL222143 | — | — | 1 | 5.43 |
| CHEMBL224272 | — | — | 1 | 5.37 |
| CHEMBL376875 | — | — | 1 | 5.24 |
| CHEMBL202936 | — | — | 1 | 5.24 |
| CHEMBL222611 | — | — | 1 | 5.22 |
| CHEMBL223275 | — | — | 1 | 5.15 |
| CHEMBL225112 | — | — | 1 | 5.13 |
| CHEMBL388500 | — | — | 1 | 5.10 |
| CHEMBL392486 | — | — | 1 | 5.08 |
| CHEMBL376191 | — | — | 1 | 5.00 |
| CHEMBL387941 | — | — | 1 | 4.89 |
| CHEMBL376192 | — | — | 1 | 4.80 |
| CHEMBL1162946 | — | — | 1 | 4.51 |
| CHEMBL174225 | — | — | 1 | 4.32 |
| CHEMBL366574 | — | — | 1 | 4.19 |
| CHEMBL376144 | — | — | 1 | - |
| CHEMBL225213 | — | — | 1 | - |
| CHEMBL376100 | — | — | 1 | - |
| CHEMBL376660 | — | — | 1 | - |
| CHEMBL225558 | — | — | 1 | - |
| CHEMBL367225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376487 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL221711 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL376874 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL221969 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL384660 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL389645 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL222143 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL224272 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL376875 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL202936 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL222611 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL223275 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL225112 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL388500 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL392486 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL376191 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL387941 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL376192 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1162946 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL174225 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL366574 | — | EC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL376144 | — | EC50 | > | 13000.0 | nM | - |
| CHEMBL225213 | — | EC50 | - | — | - | |
| CHEMBL376100 | — | EC50 | - | — | - | |
| CHEMBL376660 | — | EC50 | > | 9000.0 | nM | - |
| CHEMBL225558 | — | EC50 | > | 9000.0 | nM | - |
| CHEMBL367225 | — | EC50 | > | 74000.0 | nM | - |