Assay Detail

CHEMBL918869

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Binding

Inhibition of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B

ChEMBL ↗

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Target

Gil1 (CHEMBL1075063) ↗

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Primary target Gil1

CHEMBL1075063

Anchored from Assay target.

Protein identity Gil1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Citrobacter gillenii
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Gil1 (CHEMBL1075063) ↗

Type	SINGLE PROTEIN
Organism	Citrobacter gillenii

Publication

Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii.

Naas T, Aubert D, Ozcan A, Nordmann P.
Antimicrob Agents Chemother (2007) 51 : 1365 -1372
PubMed 17242148 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.73	8.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL777	CLAVULANIC ACID	4.0	1	8.05
CHEMBL404	TAZOBACTAM	4.0	1	7.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL777	CLAVULANIC ACID	IC50	=	9.0	nM	8.05
CHEMBL404	TAZOBACTAM	IC50	=	40.0	nM	7.40