Assay Detail
Binding
CHEMBL919048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.63 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224820 | — | — | 1 | 8.02 |
| CHEMBL222755 | — | — | 1 | 7.80 |
| CHEMBL225284 | — | — | 1 | 7.70 |
| CHEMBL389718 | — | — | 1 | 7.60 |
| CHEMBL18840 | — | — | 1 | 7.48 |
| CHEMBL225512 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224820 | — | Kd | = | 9.55 | nM | 8.02 |
| CHEMBL222755 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL225284 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL389718 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL18840 | — | Kd | = | 33.11 | nM | 7.48 |
| CHEMBL225512 | — | Kd | = | 63.1 | nM | 7.20 |