Assay Detail
Binding
CHEMBL919235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]iodoMLA from alpha-7 nAChR in rat cerebral cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.57 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | — | 1 | 9.06 |
| CHEMBL413306 | PHENYLLYCACONITINE | — | 1 | 8.78 |
| CHEMBL387363 | — | — | 1 | 8.75 |
| CHEMBL3349999 | — | — | 1 | 8.67 |
| CHEMBL442048 | — | — | 1 | 8.61 |
| CHEMBL267682 | CYCLOHEXYLLYCACONITINE | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL413306 | PHENYLLYCACONITINE | Ki | = | 1.67 | nM | 8.78 |
| CHEMBL387363 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL3349999 | — | Ki | = | 2.12 | nM | 8.67 |
| CHEMBL442048 | — | Ki | = | 2.46 | nM | 8.61 |
| CHEMBL267682 | CYCLOHEXYLLYCACONITINE | Ki | = | 26.8 | nM | 7.57 |