Assay Detail
Binding
CHEMBL919345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKBbeta by radiometric filter binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of inhibitors of protein kinase B using fragment-based lead discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.18 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374742 | — | — | 1 | 6.70 |
| CHEMBL223339 | — | — | 1 | 6.55 |
| CHEMBL227029 | — | — | 1 | 6.29 |
| CHEMBL226870 | — | — | 1 | 5.52 |
| CHEMBL228224 | — | — | 1 | 5.28 |
| CHEMBL226766 | — | — | 1 | 4.92 |
| CHEMBL428462 | — | — | 1 | 4.75 |
| CHEMBL223393 | — | — | 1 | 4.51 |
| CHEMBL227924 | — | — | 1 | 4.47 |
| CHEMBL228114 | — | — | 1 | 4.10 |
| CHEMBL390066 | — | — | 1 | 3.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374742 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL223339 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL227029 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL226870 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL228224 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL226766 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL428462 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL223393 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL227924 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL228114 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL390066 | — | IC50 | = | 135000.0 | nM | 3.87 |