Assay Detail
Binding
CHEMBL919346
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Inhibition of PKBbeta by radiometric filter binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.44 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226712 | — | — | 1 | 8.05 |
| CHEMBL228042 | — | — | 1 | 8.00 |
| CHEMBL228133 | — | — | 1 | 7.70 |
| CHEMBL227381 | — | — | 1 | 6.58 |
| CHEMBL389176 | — | — | 1 | 6.40 |
| CHEMBL227605 | — | — | 1 | 6.37 |
| CHEMBL104264 | — | — | 1 | 6.23 |
| CHEMBL375509 | — | — | 1 | 5.80 |
| CHEMBL227998 | — | — | 1 | 5.50 |
| CHEMBL376388 | — | — | 1 | 5.16 |
| CHEMBL227727 | — | — | 1 | 5.02 |
| CHEMBL389685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226712 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL228042 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL228133 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL227381 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL389176 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL227605 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL104264 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL375509 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL227998 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL376388 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL227727 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL389685 | — | IC50 | > | 100000.0 | nM | - |