Assay Detail
Binding
CHEMBL919347
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Inhibition of PKA by radiometric filter binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.57 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228042 | — | — | 1 | 7.82 |
| CHEMBL228133 | — | — | 1 | 7.48 |
| CHEMBL104264 | — | — | 1 | 7.14 |
| CHEMBL227381 | — | — | 1 | 6.77 |
| CHEMBL227605 | — | — | 1 | 6.21 |
| CHEMBL376388 | — | — | 1 | 5.28 |
| CHEMBL375509 | — | — | 1 | 5.26 |
| CHEMBL226712 | — | — | 1 | - |
| CHEMBL389176 | — | — | 1 | - |
| CHEMBL227998 | — | — | 1 | - |
| CHEMBL227727 | — | — | 1 | - |
| CHEMBL389685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228042 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL228133 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL104264 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL227381 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL227605 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL376388 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL375509 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL226712 | — | IC50 | - | — | - | |
| CHEMBL389176 | — | IC50 | - | — | - | |
| CHEMBL227998 | — | IC50 | - | — | - | |
| CHEMBL227727 | — | IC50 | - | — | - | |
| CHEMBL389685 | — | IC50 | - | — | - |