Assay Detail
Functional
CHEMBL919420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHOD |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.24 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227713 | — | — | 1 | 9.10 |
| CHEMBL415848 | — | — | 1 | 8.47 |
| CHEMBL227655 | — | — | 1 | 8.03 |
| CHEMBL390311 | — | — | 1 | 8.02 |
| CHEMBL389249 | — | — | 1 | 8.00 |
| CHEMBL227721 | — | — | 1 | 7.98 |
| CHEMBL412762 | — | — | 1 | 7.96 |
| CHEMBL390539 | — | — | 1 | 7.83 |
| CHEMBL389478 | — | — | 1 | 7.83 |
| CHEMBL227879 | — | — | 1 | 7.77 |
| CHEMBL227870 | — | — | 1 | 7.76 |
| CHEMBL227600 | — | — | 1 | 7.71 |
| CHEMBL425490 | — | — | 1 | 7.70 |
| CHEMBL227786 | — | — | 1 | 7.61 |
| CHEMBL227690 | — | — | 1 | 7.34 |
| CHEMBL227977 | — | — | 1 | 7.33 |
| CHEMBL224071 | — | — | 1 | 7.22 |
| CHEMBL413786 | — | — | 1 | 7.21 |
| CHEMBL268911 | — | — | 1 | 7.16 |
| CHEMBL227778 | — | — | 1 | 7.11 |
| CHEMBL390540 | — | — | 1 | 7.02 |
| CHEMBL2113274 | — | — | 1 | 6.95 |
| CHEMBL387982 | — | — | 1 | 6.90 |
| CHEMBL427279 | — | — | 1 | 6.78 |
| CHEMBL388720 | — | — | 1 | 6.69 |
| CHEMBL390603 | — | — | 1 | 6.68 |
| CHEMBL228014 | — | — | 1 | 6.67 |
| CHEMBL442056 | — | — | 1 | 6.59 |
| CHEMBL389054 | — | — | 1 | 6.48 |
| CHEMBL227828 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227713 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL415848 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL227655 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL390311 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL389249 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL227721 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL412762 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL390539 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL389478 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL227879 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL227870 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL227600 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL425490 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL227786 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL227690 | — | IC50 | = | 45.9 | nM | 7.34 |
| CHEMBL227977 | — | IC50 | = | 46.2 | nM | 7.33 |
| CHEMBL224071 | — | IC50 | = | 60.2 | nM | 7.22 |
| CHEMBL413786 | — | IC50 | = | 60.9 | nM | 7.21 |
| CHEMBL268911 | — | IC50 | = | 69.9 | nM | 7.16 |
| CHEMBL227778 | — | IC50 | = | 78.4 | nM | 7.11 |
| CHEMBL390540 | — | IC50 | = | 96.3 | nM | 7.02 |
| CHEMBL2113274 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL387982 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL427279 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL388720 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL390603 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL228014 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL442056 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL389054 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL227828 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL389477 | — | IC50 | = | 566.2 | nM | 6.25 |
| CHEMBL228030 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL227697 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL375709 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL228028 | — | IC50 | > | 4000.0 | nM | - |