Assay Detail
Binding
CHEMBL919510
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Inhibition of BACE1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.44 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220826 | — | — | 1 | 6.16 |
| CHEMBL220428 | — | — | 1 | 5.38 |
| CHEMBL220896 | — | — | 1 | 5.04 |
| CHEMBL220895 | — | — | 1 | 4.62 |
| CHEMBL221170 | — | — | 1 | 4.60 |
| CHEMBL220396 | — | — | 1 | 4.40 |
| CHEMBL221118 | — | — | 1 | 4.03 |
| CHEMBL220346 | — | — | 1 | 4.00 |
| CHEMBL435747 | — | — | 1 | 3.51 |
| CHEMBL61236 | — | — | 1 | 2.70 |
| CHEMBL219680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220826 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL220428 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL220896 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL220895 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL221170 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL220396 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL221118 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL220346 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL435747 | — | IC50 | = | 310000.0 | nM | 3.51 |
| CHEMBL61236 | — | IC50 | = | 2000000.0 | nM | 2.70 |
| CHEMBL219680 | — | IC50 | > | 2000000.0 | nM | - |