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Assay Detail

CHEMBL919527

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human A549 cells after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Intermediate

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions.
McCarroll AJ, Bradshaw TD, Westwell AD, Matthews CS, Stevens MF.
J Med Chem (2007) 50 : 1707 -1710
PubMed 17343370 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.30 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL151831 1 6.30
CHEMBL223210 1 6.30
CHEMBL374365 1 6.30
CHEMBL374005 1 6.30
CHEMBL222055 1 6.30
CHEMBL222686 1 6.30
CHEMBL223812 1 6.30
CHEMBL222377 1 6.30
CHEMBL222088 1 6.30
CHEMBL225016 1 6.30
CHEMBL179080 1 6.30
CHEMBL376532 1 6.30
CHEMBL177916 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL151831 IC50 = 500.0 nM 6.30
CHEMBL223210 IC50 = 500.0 nM 6.30
CHEMBL374365 IC50 = 500.0 nM 6.30
CHEMBL374005 IC50 = 500.0 nM 6.30
CHEMBL222055 IC50 = 500.0 nM 6.30
CHEMBL222686 IC50 = 500.0 nM 6.30
CHEMBL223812 IC50 = 500.0 nM 6.30
CHEMBL222377 IC50 = 500.0 nM 6.30
CHEMBL222088 IC50 = 500.0 nM 6.30
CHEMBL225016 IC50 = 500.0 nM 6.30
CHEMBL179080 IC50 = 500.0 nM 6.30
CHEMBL376532 IC50 = 500.0 nM 6.30
CHEMBL177916 IC50 = 500.0 nM 6.30