Assay Detail
Binding
CHEMBL919531
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human adipose tissue PPAR gamma expressed in HEK293 cells by PPAR-GAL4 transactivation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Adipose tissue |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.37 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.51 |
| CHEMBL87307 | — | — | 1 | 6.23 |
| CHEMBL222560 | — | — | 1 | - |
| CHEMBL38943 | GW501516 | 2.0 | 1 | - |
| CHEMBL221399 | — | — | 1 | - |
| CHEMBL222880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL87307 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL222560 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL38943 | GW501516 | EC50 | > | 10000.0 | nM | - |
| CHEMBL221399 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL222880 | — | EC50 | > | 10000.0 | nM | - |