Assay Detail
Functional
CHEMBL919560
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Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.37 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.44 |
| CHEMBL423638 | — | — | 1 | 7.35 |
| CHEMBL374427 | — | — | 1 | 7.00 |
| CHEMBL373434 | — | — | 1 | 6.66 |
| CHEMBL222480 | — | — | 1 | 6.52 |
| CHEMBL375127 | — | — | 1 | 6.51 |
| CHEMBL222732 | — | — | 1 | 6.39 |
| CHEMBL225463 | — | — | 1 | 6.35 |
| CHEMBL376711 | — | — | 1 | 6.24 |
| CHEMBL223691 | — | — | 1 | 6.21 |
| CHEMBL375309 | — | — | 1 | 6.16 |
| CHEMBL426571 | — | — | 1 | 6.16 |
| CHEMBL222531 | — | — | 1 | 6.13 |
| CHEMBL222482 | — | — | 1 | 6.09 |
| CHEMBL222902 | — | — | 1 | 6.06 |
| CHEMBL436494 | — | — | 1 | 6.05 |
| CHEMBL373514 | — | — | 1 | 6.04 |
| CHEMBL384659 | — | — | 1 | 6.03 |
| CHEMBL222146 | — | — | 1 | 6.03 |
| CHEMBL375308 | — | — | 1 | 6.02 |
| CHEMBL20403 | ZD-2138 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL423638 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL374427 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL373434 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL222480 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL375127 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL222732 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL225463 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL376711 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL223691 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL375309 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL426571 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL222531 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL222482 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL222902 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL436494 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL373514 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL384659 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL222146 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL375308 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL20403 | ZD-2138 | IC50 | > | 100000.0 | nM | - |