Assay Detail
Functional
CHEMBL919562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.26 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20403 | ZD-2138 | — | 1 | 7.08 |
| CHEMBL423638 | — | — | 1 | 6.52 |
| CHEMBL375308 | — | — | 1 | 6.32 |
| CHEMBL223691 | — | — | 1 | 6.24 |
| CHEMBL384659 | — | — | 1 | 6.14 |
| CHEMBL374427 | — | — | 1 | 6.13 |
| CHEMBL222732 | — | — | 1 | 6.12 |
| CHEMBL222480 | — | — | 1 | 6.11 |
| CHEMBL426571 | — | — | 1 | 6.10 |
| CHEMBL222146 | — | — | 1 | 6.08 |
| CHEMBL222482 | — | — | 1 | 6.07 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL222902 | — | — | 1 | - |
| CHEMBL375309 | — | — | 1 | - |
| CHEMBL375127 | — | — | 1 | - |
| CHEMBL222531 | — | — | 1 | - |
| CHEMBL376711 | — | — | 1 | - |
| CHEMBL373514 | — | — | 1 | - |
| CHEMBL373434 | — | — | 1 | - |
| CHEMBL436494 | — | — | 1 | - |
| CHEMBL225463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20403 | ZD-2138 | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL423638 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL375308 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL223691 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL384659 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL374427 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL222732 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL222480 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL426571 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL222146 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL222482 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL118 | CELECOXIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL222902 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL375309 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL375127 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222531 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL376711 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL373514 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL373434 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL436494 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225463 | — | IC50 | > | 10000.0 | nM | - |