Assay Detail
Functional
CHEMBL919564
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Antiproliferative activity against androgen-independent human PC3 cells after 72 hrs by MTT test
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.31 | 4.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374427 | — | — | 1 | 4.34 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.33 |
| CHEMBL222732 | — | — | 1 | 4.26 |
| CHEMBL222480 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374427 | — | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL118 | CELECOXIB | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL222732 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL222480 | — | IC50 | - | — | - |