Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL919604

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Plasmodium falciparum recombinant falcipain-2
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Falcipain 2 (CHEMBL5800)
Type SINGLE PROTEIN
Organism Plasmodium falciparum

Publication

Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.
Desai PV, Patny A, Sabnis Y, Tekwani B, Gut J, Rosenthal P, Srivastava A, Avery M.
J Med Chem (2004) 47 : 6609 -6615
PubMed 15588096 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.05 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL374508 E-64 1 7.82
CHEMBL224801 1 6.00
CHEMBL222870 1 5.68
CHEMBL222871 1 5.66
CHEMBL222322 1 5.41
CHEMBL222325 1 5.34
CHEMBL374510 1 5.24
CHEMBL436500 1 5.21
CHEMBL221991 1 5.21
CHEMBL438659 1 5.16
CHEMBL224803 1 5.12
CHEMBL221833 1 5.12
CHEMBL224858 1 4.91
CHEMBL374367 1 4.68
CHEMBL373909 1 4.65
CHEMBL222270 1 4.58
CHEMBL224915 1 4.56
CHEMBL224916 1 4.51
CHEMBL426564 1 4.39
CHEMBL376232 1 4.27
CHEMBL222706 1 4.26
CHEMBL222707 1 4.22
CHEMBL222708 1 4.20
CHEMBL221471 1 -
CHEMBL222709 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL374508 E-64 IC50 = 15.0 nM 7.82
CHEMBL224801 IC50 = 1000.0 nM 6.00
CHEMBL222870 IC50 = 2100.0 nM 5.68
CHEMBL222871 IC50 = 2200.0 nM 5.66
CHEMBL222322 IC50 = 3900.0 nM 5.41
CHEMBL222325 IC50 = 4600.0 nM 5.34
CHEMBL374510 IC50 = 5700.0 nM 5.24
CHEMBL436500 IC50 = 6200.0 nM 5.21
CHEMBL221991 IC50 = 6200.0 nM 5.21
CHEMBL438659 IC50 = 7000.0 nM 5.16
CHEMBL224803 IC50 = 7500.0 nM 5.12
CHEMBL221833 IC50 = 7500.0 nM 5.12
CHEMBL224858 IC50 = 12400.0 nM 4.91
CHEMBL374367 IC50 = 20800.0 nM 4.68
CHEMBL373909 IC50 = 22500.0 nM 4.65
CHEMBL222270 IC50 = 26600.0 nM 4.58
CHEMBL224915 IC50 = 27300.0 nM 4.56
CHEMBL224916 IC50 = 31100.0 nM 4.51
CHEMBL426564 IC50 = 40900.0 nM 4.39
CHEMBL376232 IC50 = 53400.0 nM 4.27
CHEMBL222706 IC50 = 54600.0 nM 4.26
CHEMBL222707 IC50 = 59900.0 nM 4.22
CHEMBL222708 IC50 = 63400.0 nM 4.20
CHEMBL221471 IC50 > 50000.0 nM -
CHEMBL222709 IC50 > 50000.0 nM -