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Assay Detail

CHEMBL919609

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by Alamar blue assay
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Intermediate

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.
Desai PV, Patny A, Sabnis Y, Tekwani B, Gut J, Rosenthal P, Srivastava A, Avery M.
J Med Chem (2004) 47 : 6609 -6615
PubMed 15588096 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 19 - -
IC50 7 5.74 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.80
CHEMBL222709 1 6.52
CHEMBL221471 1 5.72
CHEMBL55 PENTAMIDINE 4.0 1 5.70
CHEMBL222706 1 5.44
CHEMBL222325 1 5.06
CHEMBL373909 1 4.94
CHEMBL374510 1 -
CHEMBL426564 1 -
CHEMBL224858 1 -
CHEMBL224803 1 -
CHEMBL221833 1 -
CHEMBL438659 1 -
CHEMBL221991 1 -
CHEMBL436500 1 -
CHEMBL222322 1 -
CHEMBL222871 1 -
CHEMBL222870 1 -
CHEMBL376232 1 -
CHEMBL224801 1 -
CHEMBL224915 1 -
CHEMBL222270 1 -
CHEMBL222707 1 -
CHEMBL374367 1 -
CHEMBL222708 1 -
CHEMBL224916 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 160.0 nM 6.80
CHEMBL222709 IC50 = 300.0 nM 6.52
CHEMBL221471 IC50 = 1900.0 nM 5.72
CHEMBL55 PENTAMIDINE IC50 = 2000.0 nM 5.70
CHEMBL222706 IC50 = 3600.0 nM 5.44
CHEMBL222325 IC50 = 8800.0 nM 5.06
CHEMBL373909 IC50 = 11500.0 nM 4.94
CHEMBL374510 Activity - -
CHEMBL426564 Activity - -
CHEMBL224858 Activity - -
CHEMBL224803 Activity - -
CHEMBL221833 Activity - -
CHEMBL438659 Activity - -
CHEMBL221991 Activity - -
CHEMBL436500 Activity - -
CHEMBL222322 Activity - -
CHEMBL222871 Activity - -
CHEMBL222870 Activity - -
CHEMBL376232 Activity - -
CHEMBL224801 Activity - -
CHEMBL224915 Activity - -
CHEMBL222270 Activity - -
CHEMBL222707 Activity - -
CHEMBL374367 Activity - -
CHEMBL222708 Activity - -
CHEMBL224916 Activity - -