Assay Detail
Binding
CHEMBL919631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DHFR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.75 | 10.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390990 | — | — | 1 | 10.47 |
| CHEMBL388501 | — | — | 1 | 10.11 |
| CHEMBL224946 | — | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390990 | — | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL388501 | — | Ki | = | 0.077 | nM | 10.11 |
| CHEMBL224946 | — | Ki | = | 2.1 | nM | 8.68 |