Assay Detail
Binding
CHEMBL919854
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Displacement of [3H]muscimol from GABAA receptor in Sprague-Dawley rat spinal cord brainstem membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brainstem |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for glycine and gamma-aminobutyric acid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.51 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 7.82 |
| CHEMBL213907 | THIOCOLCHICOSIDE | 3.0 | 1 | 5.72 |
| CHEMBL390287 | — | — | 1 | 5.70 |
| CHEMBL223911 | — | — | 1 | 5.60 |
| CHEMBL388974 | — | — | 1 | 5.46 |
| CHEMBL376390 | — | — | 1 | 5.40 |
| CHEMBL274560 | — | — | 1 | 5.38 |
| CHEMBL227024 | — | — | 1 | 5.37 |
| CHEMBL390393 | — | — | 1 | 5.30 |
| CHEMBL426751 | — | — | 1 | 5.23 |
| CHEMBL390587 | — | — | 1 | 5.11 |
| CHEMBL228245 | — | — | 1 | 5.10 |
| CHEMBL390346 | — | — | 1 | 5.09 |
| CHEMBL390948 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL213907 | THIOCOLCHICOSIDE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL390287 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL223911 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL388974 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL376390 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL274560 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL227024 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL390393 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL426751 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL390587 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL228245 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL390346 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL390948 | — | IC50 | = | 14200.0 | nM | 4.85 |