Assay Detail
Binding
CHEMBL920022
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Inhibition of HIV1 RT Y181I mutant
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.47 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.82 |
| CHEMBL223769 | — | — | 1 | 6.16 |
| CHEMBL225416 | — | — | 1 | 6.10 |
| CHEMBL224590 | — | — | 1 | 5.68 |
| CHEMBL139532 | — | — | 1 | 5.40 |
| CHEMBL225049 | — | — | 1 | 4.75 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 4.44 |
| CHEMBL388753 | — | — | 1 | 4.40 |
| CHEMBL342620 | — | — | 1 | - |
| CHEMBL140665 | — | — | 1 | - |
| CHEMBL376535 | — | — | 1 | - |
| CHEMBL225467 | — | — | 1 | - |
| CHEMBL225048 | — | — | 1 | - |
| CHEMBL376534 | — | — | 1 | - |
| CHEMBL224939 | — | — | 1 | - |
| CHEMBL223609 | — | — | 1 | - |
| CHEMBL224450 | — | — | 1 | - |
| CHEMBL224516 | — | — | 1 | - |
| CHEMBL223178 | — | — | 1 | - |
| CHEMBL225004 | — | — | 1 | - |
| CHEMBL224394 | — | — | 1 | - |
| CHEMBL225050 | — | — | 1 | - |
| CHEMBL224699 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL223769 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL225416 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL224590 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL139532 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL225049 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL388753 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL342620 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140665 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL376535 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225048 | — | IC50 | - | — | - | |
| CHEMBL376534 | — | IC50 | - | — | - | |
| CHEMBL224939 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223609 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL224450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL224516 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223178 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225004 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL224394 | — | IC50 | - | — | - | |
| CHEMBL225050 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL224699 | — | IC50 | > | 10000.0 | nM | - |