Assay Detail
Binding
CHEMBL920258
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Displacement of [3H]KA from rat recombinant GluR6 expressed in Sf9 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Glutamate receptor ionotropic, kainate 2 (CHEMBL3607) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.57 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370038 | — | — | 1 | 7.72 |
| CHEMBL388746 | — | — | 1 | 7.41 |
| CHEMBL13378 | (R,S)-AMPA | — | 1 | - |
| CHEMBL193087 | — | — | 1 | - |
| CHEMBL372643 | — | — | 1 | - |
| CHEMBL370941 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370038 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL388746 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL13378 | (R,S)-AMPA | Ki | > | 1000.0 | nM | - |
| CHEMBL193087 | — | Ki | > | 100.0 | nM | - |
| CHEMBL372643 | — | Ki | > | 100.0 | nM | - |
| CHEMBL370941 | — | Ki | > | 100.0 | nM | - |