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Assay Detail

CHEMBL920404

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of vaccinia virus system-induced human NOS expressed in BSC1 cells
ChEMBL ↗
77
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BSC-1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
Davey DD, Adler M, Arnaiz D, Eagen K, Erickson S, Guilford W, Kenrick M, Morrissey MM, Ohlmeyer M, Pan G, Paradkar VM, Parkinson J, Polokoff M, Saionz K, Santos C, Subramanyam B, Vergona R, Wei RG, Whitlow M, Ye B, Zhao ZS, Devlin JJ, Phillips G.
J Med Chem (2007) 50 : 1146 -1157
PubMed 17315988 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 77 7.08 8.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL222364 — — 1 8.31
CHEMBL376733 — — 1 8.25
CHEMBL220632 — — 1 8.23
CHEMBL442041 — — 1 8.15
CHEMBL220880 — — 1 8.12
CHEMBL223788 — — 1 8.05
CHEMBL385325 — — 1 8.00
CHEMBL375404 — — 1 8.00
CHEMBL373623 — — 1 7.96
CHEMBL223634 — — 1 7.89
CHEMBL424928 — — 1 7.89
CHEMBL221264 — — 1 7.80
CHEMBL223385 — — 1 7.80
CHEMBL385324 — — 1 7.75
CHEMBL223792 — — 1 7.75
CHEMBL376632 — — 1 7.70
CHEMBL374681 — — 1 7.64
CHEMBL220834 — — 1 7.62
CHEMBL290548 — — 1 7.62
CHEMBL427062 — — 1 7.60
CHEMBL221208 — — 1 7.60
CHEMBL374319 — — 1 7.60
CHEMBL376713 — — 1 7.55
CHEMBL220156 — — 1 7.47
CHEMBL387348 — — 1 7.38
CHEMBL223782 — — 1 7.32
CHEMBL411343 — — 1 7.16
CHEMBL223791 — — 1 7.14
CHEMBL373881 — — 1 7.13
CHEMBL220771 — — 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL222364 — IC50 = 4.9 nM 8.31
CHEMBL376733 — IC50 = 5.6 nM 8.25
CHEMBL220632 — IC50 = 5.9 nM 8.23
CHEMBL442041 — IC50 = 7.0 nM 8.15
CHEMBL220880 — IC50 = 7.5 nM 8.12
CHEMBL223788 — IC50 = 9.0 nM 8.05
CHEMBL385325 — IC50 = 10.0 nM 8.00
CHEMBL375404 — IC50 = 10.0 nM 8.00
CHEMBL373623 — IC50 = 11.0 nM 7.96
CHEMBL223634 — IC50 = 13.0 nM 7.89
CHEMBL424928 — IC50 = 13.0 nM 7.89
CHEMBL221264 — IC50 = 16.0 nM 7.80
CHEMBL223385 — IC50 = 16.0 nM 7.80
CHEMBL223792 — IC50 = 18.0 nM 7.75
CHEMBL385324 — IC50 = 18.0 nM 7.75
CHEMBL376632 — IC50 = 20.0 nM 7.70
CHEMBL374681 — IC50 = 23.0 nM 7.64
CHEMBL220834 — IC50 = 24.0 nM 7.62
CHEMBL290548 — IC50 = 24.0 nM 7.62
CHEMBL427062 — IC50 = 25.0 nM 7.60
CHEMBL221208 — IC50 = 25.0 nM 7.60
CHEMBL374319 — IC50 = 25.0 nM 7.60
CHEMBL376713 — IC50 = 28.0 nM 7.55
CHEMBL220156 — IC50 = 34.0 nM 7.47
CHEMBL387348 — IC50 = 42.0 nM 7.38
CHEMBL223782 — IC50 = 48.0 nM 7.32
CHEMBL411343 — IC50 = 70.0 nM 7.16
CHEMBL223791 — IC50 = 72.0 nM 7.14
CHEMBL373881 — IC50 = 74.0 nM 7.13
CHEMBL220771 — IC50 = 80.0 nM 7.10
CHEMBL385334 — IC50 = 85.0 nM 7.07
CHEMBL374552 — IC50 = 100.0 nM 7.00
CHEMBL220121 — IC50 = 110.0 nM 6.96
CHEMBL373919 — IC50 = 120.0 nM 6.92
CHEMBL220270 — IC50 = 140.0 nM 6.85
CHEMBL220123 — IC50 = 160.0 nM 6.80
CHEMBL376237 — IC50 = 160.0 nM 6.80
CHEMBL436535 — IC50 = 210.0 nM 6.68
CHEMBL223515 — IC50 = 220.0 nM 6.66
CHEMBL387349 — IC50 = 230.0 nM 6.64
CHEMBL223045 — IC50 = 245.0 nM 6.61
CHEMBL220630 — IC50 = 260.0 nM 6.58
CHEMBL373868 — IC50 = 260.0 nM 6.58
CHEMBL223043 — IC50 = 274.0 nM 6.56
CHEMBL223840 — IC50 = 320.0 nM 6.50
CHEMBL374132 — IC50 = 320.0 nM 6.50
CHEMBL220122 — IC50 = 340.0 nM 6.47
CHEMBL219792 — IC50 = 340.0 nM 6.47
CHEMBL222362 — IC50 = 350.0 nM 6.46
CHEMBL373546 — IC50 = 370.0 nM 6.43