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Assay Detail

CHEMBL920405

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tetracycline system-induced human NOS expressed in SF9 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
Davey DD, Adler M, Arnaiz D, Eagen K, Erickson S, Guilford W, Kenrick M, Morrissey MM, Ohlmeyer M, Pan G, Paradkar VM, Parkinson J, Polokoff M, Saionz K, Santos C, Subramanyam B, Vergona R, Wei RG, Whitlow M, Ye B, Zhao ZS, Devlin JJ, Phillips G.
J Med Chem (2007) 50 : 1146 -1157
PubMed 17315988 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.85 8.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL220632 1 8.35
CHEMBL376733 1 8.26
CHEMBL220880 1 8.15
CHEMBL385324 1 8.00
CHEMBL427062 1 7.96
CHEMBL290548 1 7.92
CHEMBL376632 1 7.85
CHEMBL221208 1 7.80
CHEMBL220771 1 7.34
CHEMBL222362 1 6.89
CHEMBL220172 1 -
CHEMBL220511 1 -
CHEMBL220824 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL220632 IC50 = 4.5 nM 8.35
CHEMBL376733 IC50 = 5.5 nM 8.26
CHEMBL220880 IC50 = 7.1 nM 8.15
CHEMBL385324 IC50 = 10.0 nM 8.00
CHEMBL427062 IC50 = 11.0 nM 7.96
CHEMBL290548 IC50 = 12.0 nM 7.92
CHEMBL376632 IC50 = 14.0 nM 7.85
CHEMBL221208 IC50 = 16.0 nM 7.80
CHEMBL220771 IC50 = 46.0 nM 7.34
CHEMBL222362 IC50 = 130.0 nM 6.89
CHEMBL220172 IC50 - -
CHEMBL220511 IC50 - -
CHEMBL220824 IC50 - -